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SPROUT User Publications

Structure-based discovery of antibacterial drugs

Katie J. Simmons, Ian Chopra, Colin W. G. Fishwick

Nature Reviews Microbiology
2010, 8 (7), pp 501-510

ABSTRACT

Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases

Matthew Davies, Timo Heikkila, Glenn A. McConkey, Colin W. G. Fishwick, Mark R. Parsons, A. Peter Johnson

J. Med. Chem.
2009, 52 (9), pp 2683-2693

ABSTRACT

Design and synthesis of new hydroxyethylamines as inhibitors of D-alanyl-D-lactate ligase (VanA) and D-alanyl-D-alanine ligase (DdlB)

Matej Sova, Gasper Cadez, Samo Turk, Vita Majce, Slovenko Polanc, Sarah Batson, Adrian J. Lloyd, David I. Roper, Colin W. G. Fishwick, Stanislav Gobec

Bioorg. Med. Chem. Lett.
2009, 19 (5), pp 1376-1379

ARTICLE

Synthesis of de novo designed small-molecule inhibitors of bacterial RNA polymerase

Anil K. Agarwal, A. Peter Johnson, Colin W. G. Fishwick

Tetrahedron
2008, 64, pp 10049-10054

ARTICLE

Design and SAR of selective T-type calcium channel antagonists containing a biaryl sulfonamide core

Jon J. Hangeland, Daniel L. Cheney, Todd J. Friends, Stephen Swartz, Paul C. Levesque, Adam J. Rich, Lucy Sun, Terry R. Bridal, Leonard P. Adam, Diane E. Normandin, Natesan Murugesan, William R. Ewing

Bioorg. Med. Chem. Lett.
2008, 18 (2), pp 474-478

ARTICLE

Design and synthesis of potent inhibitors of the malaria parasite dihydroorotate dehydrogenase

Timo Heikkila, Christopher Ramsey, Matthew Davies, Christophe Galtier, Andrew M. W. Stead, A. Peter Johnson, Colin W. G. Fishwick, Andrew N. Boa, Glenn A. McConkey

J. Med. Chem.
2007, 50 (2), pp 186-191

ABSTRACT

The first de novo designed inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase

Timo Heikkila, Srinath Thirumalairajan, Matthew Davies, Mark R. Parsons, A. Glenn McConkey, Colin W. G. Fishwick, A. Peter Johnson

Bioorg. Med. Chem. Lett.
2006, 16 (1), pp 88-92

ARTICLE

A novel de novo designed inhibitor of D-ala-D-ala ligase from E.coli.

Gilbert E. Besong, Julieanne M. Bostock, Will Stubbings, Ian Chopra, David I. Roper, Adrian J. Lloyd, Colin W. G. Fishwick, A. Peter Johnson

Angew. Chem. Int. Ed. Engl.
2005, 44 (39), pp 6403 - 6406

ABSTRACT

The first de novo-designed antagonists of the human NK2 receptor

Mohammed A. Ali, Nirmala Bhogal, John B. C. Findlay, Colin W. G. Fishwick

J. Med. Chem.
2005, 48 (18), pp 5655-5658

ABSTRACT

Design, synthesis, and biological evaluation of potent and selective amidino bicyclic factor Xa inhibitors

Qi Han, Celia Dominguez, Pieter F. W. Stouten, Jeongsook M. Park, Daniel E. Duffy, Robert A. Galemmo, Jr., Karen A. Rossi, Richard S. Alexander, Angela M. Smallwood, Pancras C. Wong, Matthew M. Wright, Joseph M. Luettgen, Robert M. Knabb, Ruth R. Wexler

J. Med. Chem.
2000, 43 (23), pp 4398-4415

ABSTRACT

Molecular modeling in the discovery of drug leads

George W. A. Milne, Shaomeng Wang, and Marc C. Nicklaus

J. Chem. Inf. Comp. Sci.
1996, 36 (4), pp 726-730

ABSTRACT